How does CalmPRO5 work ? When evaluating the effectiveness of a supplement like CalmPro5, it’s important to consider both user anecdotal evidence and the scientific rationale behind its formulation. Many users report noticeable improvements in their overall well-being after incorporating CalmPro5 into their daily routines. The ingredients are carefully chosen for their historical use in traditional medicine, often aimed at calming the nervous system and enhancing mood.